prikaz prve stranice dokumenta Molekularni mehanizmi staničnog reprogramiranja kod besmrtne meduze Turritopsis dohrnii (Cnidaria: Hydrozoa)
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undergraduate thesis
Molekularni mehanizmi staničnog reprogramiranja kod besmrtne meduze Turritopsis dohrnii (Cnidaria: Hydrozoa)
2023. urn:nbn:hr:226:628656
Domazet, Ema
University of Split
University Department of Marine Studies

Cite this document

Domazet, E. (2023). Molekularni mehanizmi staničnog reprogramiranja kod besmrtne meduze Turritopsis dohrnii (Cnidaria: Hydrozoa) (Undergraduate thesis). Split: University of Split. Retrieved from https://urn.nsk.hr/urn:nbn:hr:226:628656

Domazet, Ema. "Molekularni mehanizmi staničnog reprogramiranja kod besmrtne meduze Turritopsis dohrnii (Cnidaria: Hydrozoa)." Undergraduate thesis, University of Split, 2023. https://urn.nsk.hr/urn:nbn:hr:226:628656

Domazet, Ema. "Molekularni mehanizmi staničnog reprogramiranja kod besmrtne meduze Turritopsis dohrnii (Cnidaria: Hydrozoa)." Undergraduate thesis, University of Split, 2023. https://urn.nsk.hr/urn:nbn:hr:226:628656

Domazet, E. (2023). 'Molekularni mehanizmi staničnog reprogramiranja kod besmrtne meduze Turritopsis dohrnii (Cnidaria: Hydrozoa)', Undergraduate thesis, University of Split, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:226:628656

Domazet E. Molekularni mehanizmi staničnog reprogramiranja kod besmrtne meduze Turritopsis dohrnii (Cnidaria: Hydrozoa) [Undergraduate thesis]. Split: University of Split; 2023 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:226:628656

E. Domazet, "Molekularni mehanizmi staničnog reprogramiranja kod besmrtne meduze Turritopsis dohrnii (Cnidaria: Hydrozoa)", Undergraduate thesis, University of Split, Split, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:226:628656

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Metadata
TitleMolekularni mehanizmi staničnog reprogramiranja kod besmrtne meduze Turritopsis dohrnii (Cnidaria: Hydrozoa)
Title (english)Molecular mechanisms of cellular reprogramming in the immortal jellyfish Turritopsis dohrnii (Cnidaria: Hydrozoa)
AuthorEma Domazet
MentorŽeljka Trumbić (mentor)
Committee memberVedran Poljak (predsjednik povjerenstva)
Committee memberŽeljka Trumbić (član povjerenstva)
Committee memberMirela Petrić (član povjerenstva)
GranterUniversity of Split
(University Department of Marine Studies)
Split
Defense date and country2023-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Koljeno žarnjaci (Cnidaria) uključuje vodene organizme koji imaju radijalnu simetriju i posjeduju knidocite, žarne stanice. Među ovim organizmima postoje zanimljive vrste koje su odvijek privlačile pozornost svojom jedinstvenom razvojnom plastičnošću, sposobnošću regeneracije, pa čak i ontogenetskim preokretima, odnosno sposobnošću razvoja unatrag. Koliko je trenutno poznato, samo vrsta Turritopsis dohrnii ima sposobnost transdiferencijacije ili pomlađivanja, dediferencijacije stanica. Kada se potpuno diferencirana i spolno zrela meduza nađe u nepovoljnim uvjetima (fizičko oštećenje, stres, nedostatak hrane), započinje redukciju u fazu nediferencirane ciste iz koje se nakon nekog vremena razvije stolon koji daje polipe. Zbog sposobnosti ponavljanja svog životnog ciklusa, naziva se besmrtnom meduzom. Proučavanjem genoma i transkriptoma ove vrste u sva četiri razvojna stadija omogućen je početni uvid u molekularne mehanizme koji bi mogli biti glavni pokretači ovog ontogenskog preokreta. Tijekom razvoja iznimno su važni procesi povezani s replikacijom DNA, održavanjem i popravkom te, stabilnošću genoma, održavanjem telomera i otpornost na oksidativni stres te poboljšana međustanična komunikacija vezana za razvoj živčanog sustava.
Abstract (english)
The phylum Cnidaria includes aquatic organisms that have radial symmetry and possess cnidocytes. Among these organisms, interesting species have always attracted attention with their unique developmental plasticity, ability to regenerate, and perform even ontogenetic reversals. According to current literature, only the species Turritopsis dohrnii has the ability to transdifferentiate or rejuvenate, i.e., dedifferentiate its cells. When a fully differentiated and sexually mature jellyfish finds itself in unfavorable conditions (physical damage, stress, starvation), it begins its reduction into the stage of an undifferentiated cyst, from which after some time a stolon develops that produces polyps. Because of its ability to repeat its life cycle, it is called an immortal jellyfish. By studying the genome and transcriptome of this species in all four developmental stages, an initial insight into the molecular mechanisms responsible for this ontogenic reversal was provided. During development, the processes related to DNA replication, maintenance and repair, genome stability, telomere maintenance and resistance to oxidative stress and improved intercellular communication related to the development of the nervous system are extremely important.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:226:628656
Study programmeTitle: Undergraduate university studies Marine Biology and Technology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biologije i tehnologije mora (sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biologije i tehnologije mora)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2023-12-20 08:28:28